The Mystery of Methylation: Understanding Overmethylation and Undermethylation

The Mystery of Methylation: Understanding Overmethylation and Undermethylation

Methylation, a crucial biochemical process in the body, plays a pivotal role in various bodily functions. As a Herbal Naturopath practicing functional medicine, I often delve into the intricacies of methylation to identify root causes behind health issues. Today, let's explore two sides of the methylation coin – Overmethylation and Undermethylation – their meaning, signs, symptoms, and a holistic overview of treatment.


Understanding Methylation:

Methylation involves the transfer of a methyl group (one carbon atom bonded to three hydrogen atoms) to various molecules, such as proteins, DNA, and neurotransmitters. This process regulates gene expression, detoxification, neurotransmitter balance, and overall cellular function.

Methylation status, whether over or under, is influenced by a complex interplay of genetic, environmental, and lifestyle factors. Understanding why individuals may fall into either category requires insight into the intricate mechanisms that govern methylation processes.

Genetic Factors:

  • Genetic variations, such as mutations in the MTHFR gene, play a pivotal role. These mutations can impact the efficiency of the methylation pathway, leading to either excessive or inadequate methylation.

Environmental Exposures:

  • Environmental factors, including exposure to toxins and pollutants, can disrupt the delicate balance of methylation. Prolonged exposure to environmental stressors may contribute to imbalances in the methylation process.

Nutrient Intake:

  • Adequate intake of essential nutrients is crucial for proper methylation. B-vitamins, particularly folate, B6, and B12, are essential cofactors in the methylation pathway. Insufficient or excessive intake of these nutrients can tilt the balance towards overmethylation or undermethylation.

Lifestyle Factors:

  • Stress, both physical and emotional, can impact methylation. Chronic stress may deplete methyl donors, affecting the overall methylation status. Additionally, lifestyle factors such as diet, sleep, and exercise play a role in maintaining methylation balance.

Epigenetic Modifications:

  • Epigenetic changes, alterations in gene expression without changes to the underlying DNA sequence, can influence methylation patterns. Factors like diet, stress, and environmental exposures can induce epigenetic modifications, affecting methylation.

Individual Biochemistry:

  • Each person's biochemistry is unique. Variations in metabolic pathways, enzyme activity, and overall biochemical individuality contribute to whether an individual tends towards overmethylation or undermethylation.

Health History:

  • Past health issues and medical history can impact methylation status. Chronic conditions, infections, or other health challenges may leave a lasting imprint on the body's methylation processes.



When the methylation process occurs excessively, it leads to overmethylation. This can result in an abundance of methyl groups, affecting neurotransmitter levels, such as serotonin, dopamine, and norepinephrine. Common signs and symptoms of overmethylation may include and not limited to:

  • Anxiety or restlessness
  • High energy levels
  • Insomnia
  • Obsessive-compulsive tendencies
  • Allergies and sensitivities
  • Digestive issues



Conversely, undermethylation occurs when the methylation process is insufficient. This can lead to a shortage of methyl groups, impacting neurotransmitter production and overall cellular function. Signs and symptoms of undermethylation may manifest as (not an exhausted list):

  • Depression or low mood
  • Fatigue or low energy levels
  • Histamine intolerance
  • Seasonal allergies
  • Impaired detoxification
  • Obsessive-compulsive tendencies


Holistic Treatment Approach:

As a Herbal Naturopath, my approach to addressing methylation imbalances involves holistic interventions. While a personalized program is essential, here are general recommendations:

Nutritional Support:

  • Focus on nutrient-rich foods, including leafy greens, nuts, seeds, and organic meats.
  • Consider supplements like B-vitamins, zinc, and magnesium.

Herbal Support:

  • Adaptogenic herbs such as Ashwagandha and Rhodiola may help balance stress responses.
  • Include herbs like Holy Basil for its antioxidant properties.

Lifestyle Modifications:

  • Stress management through practices like yoga, meditation, and deep breathing.
  • Adequate sleep is crucial for overall well-being.

Detoxification Support:

  • Consider incorporating foods and herbs that support liver function, such as dandelion root and milk thistle.


Understanding the significance of a personalized protocol is crucial for optimizing your health. While the general recommendations provided can serve as a foundational approach, a one-size-fits-all solution may not address your unique biochemical and genetic makeup.

As a Herbal Naturopath practicing functional medicine, I emphasize the importance of individualized care. Every person's body is distinct, and factors such as genetic mutations, biochemical imbalances, and specific health history play a vital role in crafting an effective protocol.

By coming to see me, we can delve deeper into your health journey, conduct comprehensive functional medicine testing, and identify the specific nuances that contribute to your health issues. This personalized approach allows for a targeted and tailored protocol that addresses the root cause of your symptoms.

Moreover, our consultation provides an opportunity for detailed discussions about your lifestyle, stressors, and goals. This holistic understanding enables me to create a protocol that aligns with your unique needs, ensuring a more precise and effective intervention.

In essence, while the general information shared here lays a foundation, the true power of healing lies in a personalized protocol designed specifically for you. Your journey to optimal health is unique, and a personalized consultation allows us to embark on this path together, addressing your health concerns with precision and care.


Herbal Naturopathic/Nutritional Appointments - In-Person or On line

Embark on your holistic healing journey by scheduling an appointment with us at ADHD Naturopathic Clinic (formerly The Green Gingko). As an Herbal Naturopath specializing in ADHD, genetic mutations, and various health issues, we offer personalized, comprehensive consultations tailored to your unique needs. Our approach integrates traditional knowledge with modern understanding, emphasizing the interconnectedness of mind, body, and spirit. Whether you're seeking support for ADHD, exploring genetic mutations, or addressing chronic conditions, we're committed to guiding you towards optimal well-being. Together, let's unravel the intricacies of your health, incorporating herbal remedies, lifestyle adjustments, and evidence-based practices. Take the first step towards a balanced and vibrant life—book your appointment today and embark on a transformative journey towards holistic healing.



  • Smith AD, Refsum H. Homocysteine, B vitamins, and cognitive impairment. Annu Rev Nutr. 2016;36:211-239.
  • Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose, and Efficacy—A Review. Nutrients. 2016;8(2):68.


This website is for informational purposes only.  
Back to blog

Contact form